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Therapy for CN1 hyperbilirubinemia can be safe and effective to prevent kernicterus and has included life long phototherapy, bilirubin binders (agar, cholestyramine, and calcium phosphate) to interrupt the enterohepatic circulation, plasmapheresis for acute episodes of severe hyperbilirubinemia related to intercurrent illness and, rarely, heme oxygenase inhibition to prevent bilirubin production

Mix gently

Liposomal forms or intravenous administration improve absorption

2 hrs after reaching the maximum plasmatic concentration, the concentration of active drug is higher in the synovial fluid than in the plasma and the rest is reached in a period of 12 hrs